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From lab to life: functional validation of AML data
Understanding AML resistance is only part of the battle. Translating this knowledge into actionable therapies is where the TALETE project truly shines. By employing sophisticated in vitro models, we are validating our findings and exploring new treatment approaches. These models replicate AML interactions with the BM microenvironment, focusing on immune cell behaviors, stromal cell signaling, and metabolic changes.
What we are testing
Key experiments include studying Treg induction by tumor-associated macrophages, analyzing AML-stromal cell interactions, and investigating how MSCs influence macrophage polarization. These studies test the impact of novel compounds like IDO1 inhibitors and AHR antagonists, assessing their potential to disrupt resistance mechanisms.
Building better therapies
These efforts aim to refine existing therapies and develop new ones tailored to the unique needs of AML patients. By addressing the root causes of resistance, TALETE is paving the way for treatments that are not only more effective but also more enduring.